Sunday, March 1, 2020

Sodium imbalance in blood ???

It is essential to perceive the inconveniences of the matured individuals who regularly grievance of differing sodium levels in the blood. Salt, which is a mix of sodium and chloride components, is answerable for this condition which is for the most part found in elderly individuals. Expending a lot of salt may prompt numerous medical problems. A sound individual can expend up to 2.4 grams salt in a day. It is equivalent to a teaspoon loaded with salt. The additional salt that arrives at the body may prompt hypertension and changing sodium levels.

It is through the water in the cells that the electric flows are passed starting with one cell then onto the next in our body. In the event that these flows can't be directed through water, at that point it would rely upon electrolytes like sodium, calcium and magnesium for this reason. High or low degrees of one of these electrolytes could upset the exchange of the electric flows through the cells. This would then influence the working of the body. The kidneys, adrenal organ and the nerve center in the mind are liable for adjusting the sodium levels in the body. Thus, the parity of sodium could be lost of one of these are not in acceptable condition.

Side effects

There aren't any one of a kind side effects when the sodium levels drop minutely or for a drawn out period. Be that as it may, one must be cautious in the event that he/she shows obviousness, regurgitating sensations, weakness and depletion. On the off chance that the sodium levels are brought radically it would lead down to mental trouble, absence of focus, shuddering and obviousness. On the off chance that the patient stays oblivious for quite a while, at that point it might prompt senseless. This could additionally prompt the demise of the patient.

Causes

The medications that are typically recommended for kidney sicknesses, liver infections, pneumonia, gastro entocritis, hypo thyrodism, lung disease, lymphoma, stroke and tumors could bring about sodium irregularity. In addition, a few prescriptions for diabetes, hypertension and heart infirmities also may prompt shifting levels in sodium. On the off chance that you experience weariness, sickness, obviousness and abrupt memory misfortune following taking these drugs, you could presume sodium lopsidedness. A couple of against maniacal medications and agony executioners also could bring down the sodium level in the body. The initial two weeks after you begin taking meds is noteworthy. There are heaps of individuals who take similar meds for diabetes and circulatory strain for a considerable length of time. The symptoms of such medications could be sodium awkwardness. Foods grown from the ground are the regular wellsprings of sodium and potassium. Thus, it is imperative to remember new foods grown from the ground for your day by day diet.

Treatment

There is no compelling reason to look for treatment for exact moment drop in the sodium levels. Be that as it may, it might be not kidding on the off chance that it dips under 120. Sodium could then be moved into the body gradually as dribbles. Whenever given quickly, at that point it could influence the mind and further lead to genuine conditions.

High sodium level

High sodium could be the consequence of low water content in the body. Sodium increments when you can't feel thirst or the body loses an excess of water. The individuals who are determined to have high diabetes and the individuals who take medications for obstruction and challenges for pee could encounter high sodium levels. The side effects of high sodium are nearly as comparable as the indications of low sodium. Depletion and obviousness and palpitation and seizure could be the manifestations of high sodium levels. High pressure may build the creation of the counter diuretic hormones which hinders the pee creation. Mental pressure could bring down the pee creation which may additionally build the sodium levels. Unexpected drop in sodium may modify the conduct of an individual and prompts temperament swings also. Exhaustion, outrage, disarray, incapable to take choices and shortcoming might be the consequence of sodium getting brought down in the mind.

Lemon juice

Drinking salted lemon squeeze and delicate coconut water could facilitate the state of sodium irregularity. Be that as it may, the individuals who have hypertension and kidney infections ought to expend these beverages simply in the wake of counseling the specialist.

low blood sugar - simple signs

Many grumble of anxiety or sickness when their glucose level out of nowhere drops. A decent eating routine that contains protein, solid fats and sugar could help forestall this condition. Be that as it may, you could encounter abrupt drop in the glucose levels regardless of eating a sound and even eating routine. The individuals who experience unexpected drop in glucose or glucose ought to be cautious about these manifestations.

Not ready to take choices
Glucose is a significant wellspring of vitality in the body. The cerebrum utilizes half of this vitality for working appropriately. At the point when the glucose level unexpectedly drops, it would be hard for the mind take the correct choices. You could likewise lose your fixation. Eating a solid bite or an early afternoon feast could guarantee enough stockpile of glucose and astounding working of the cerebrum too.

A lot of perspiring

It is very normal to perspire a ton during the unforgiving summers or after an extreme meeting of exercise. In any case, perspiring lavishly while sitting at home or at the workplace, without physical effort, could be an indication of dropping glucose. Attempt to eat anything promptly when you notice it. As a rule, this occurs in the first part of the day as the sugar level drops in the night.

Awakening around evening time

Broken rest could be the consequence of dropping glucose. In the event that you wake up ceaselessly in rest, it could be a result of the glucose. The body produces pressure hormones when the sugar level in the blood goes down. This upsets the rest.

Emotional episodes

Unexplained emotional episodes also could be brought about by dropping glucose. On the off chance that you are upbeat at one minute and, at that point promptly turn bleak, you could presume that the sugar has gone down. In the event that you experience abrupt and unexplained emotional episodes, don't stop for a second to counsel a specialist.

Expanded heart pulsates

In the event that you feel that your heart is thumping quickly than it should, at that point your glucose level must be dropping. Have a go at eating crisp natural products or organic product juices to stay away from this condition.

Thursday, February 27, 2020

New solution against epilepsy

An ongoing report has offered new trust in guardians who have a kid with an uncommon yet genuine type of epilepsy, epileptic encephalopathy (EE).

Better approaches for sequencing the human genome mean geneticists and hereditary guides have considerably more to state to guardians who wonder if future youngsters may convey the infection, said co-senior creator Heather Mefford from the University of Washington School of Medicine.

These advances offer bits of knowledge for us all since they are a piece of the developing investigation of mosaicism - the way that a significant number of us don't in actuality have only one genome in us. We are what researchers call mosaics - lots of cells that may have various genotypes covered profound inside us.

A small change happens some time after treatment when cells are partitioning, which requires replicating the whole DNA. On the off chance that one of those cells makes a replicating blunder that presents a transformation. All the cells that originate from that cell will convey a similar transformation. So you end up with a mosaic example where a few cells have the change and a few cells don't. That is the mosaic," Mefford said.

The way that, state, 10 percent of your cells dissipated all through your body may be not the same as different cells might be totally immaterial. Yet, in the event that 10 percent of your sperm or oocytes have the change, that could be a major issue if that transformation influences the mental health of the kid.

A central issue from any parent of a youngster with EE is what are the chances that our other kids may have this condition? For a considerable length of time, guardians whose kid had epilepsy were advised there's a 1 to 5 percent chance that other youngsters may acquire the change. This depended on clinical proof - the quantities of reoccurrences doctors found in the center.

However, equipped with progressively exact testing, the geneticists discovered parental mosaicism that wasn't handily recognized before in around 10 percent of families, putting these families at higher danger of passing the change to another youngster. What this implies in functional terms is that this little gathering likely records for the vast majority of the reoccurrences. For certain guardians, there's uplifting news: if this parental mosaicism was not recognized, your chances of having another such kid with epilepsy could be significantly less than 1 percent.

'We have the innovation to select small cells in an ocean of in any case typical cells. The level of families where we can distinguish mosaicism in the parent is higher than the greater part of us figured it would be. While the general repeat hazard (over all families) is around 1 percent, for those families where we can locate the mosaic transformation in the guardians, it is anything but a 1 percent chance. It's a lot higher than that. Furthermore, we presently have the apparatuses to help give them that data, and help them with better family arranging and dynamic not far off,' Mefford said.

"Our investigation concentrated on patients with extreme epilepsy. However, the finding that 10 percent of the guardians have mosaicism may really apply to an expansive scope of different issue, including chemical imbalance and scholarly incapacity," Mefford included.

The examination is distributed in the New England Journal of Medicine.

Eating Orange, grape daily reduce the risk of dementia

Accoring to a most recent investigation, more seasoned individuals who expend orange and grapes consistently can bring down the danger of dementia by 23%.

Specialists from Tohuku University in Japan have discovered that every day admission of any citrus natural product, for example, orange, lemon can cut the odds of building up the hopeless cerebrum condition by just about a quarter.

The discoveries recommended that the citrus extract contains a synthetic compounds nobiletin, in which the creature tests has appeared to slow or turn around debilitation of memory.

For the exploration, the group dissected a gathering of in excess of 13,000 more seasoned grown-ups for as long as seven years to perceive what number of created dementia. The paces of dementia among those eating citrus natural products at any rate once a day were essentially lower than in volunteers having them not as much as two times every week.

Wednesday, May 16, 2018

Humble drumstick is the nutrient factory

On the off chance that you are searching for vegetables not harmed with pesticides and synthetic manures, look no farther than your patio. The humble moringa tree is a one-stop answer to all your wholesome needs. You can eat its leaves, blossoms and the seed-units apropos called drumsticks.

Moringa is no more abnormal to the Malayali diet. The lean drumsticks are stuffed with supplements, your grandma would let you know.

Moringa leaves are plentiful in nutrients and minerals. It has nutrient A, nutrient B6, nutrient C, iron, riboflavin, magnesium, manganese and protein. Moringa leaves, similar to the seed-units, are loaded down with cancer prevention agents that forestalls the free radicals and ensures you against heart infections and Type 2 diabetes.

The miracle leaves additionally contain beta carotene and cancer prevention agents, for example, quercetin that assists lower with blooding pressure and chlorogenic corrosive that controls glucose levels. The isothyocyanates in moringa leaves assist keep with blooding sugar levels in charge.

Moringa leaves are additionally acceptable to treat aggravation and contaminations. A standard admission of the leaves battles of the development of cholesterol. The leaves are useful for the skin and hair as well. The juice of the leaves help lighten the stomach cramps related with feminine cycle. A bunch of goes home as a decent diuretic. Indeed, even the foundation of the tree is utilized as a medication.

For processing

Normal utilization of drumsticks helps processing. The B complex nutrients in moringa leaves and seed-cases, for example, niacin, riboflavin, folic corrosive and pyridoxine, help processing. These nutrients manage the way toward separating starches, proteins and fats.

The fiber in moringa leaves are a decent solution for obstruction. They additionally do ponders in treating gastric difficulties and ulcers. Moringa has anti-toxin properties that wards of unsafe germs and forestalls looseness of the bowels.

For the bones

Drumsticks are extraordinary for the bones since they contain calcium, iron and a few fundamental nutrients. Odds of osteoporosis is lesser in individuals who incorporate moringa in their day by day diet. The cancer prevention agents and antioxidantal mixes in moringa leaves reinforce the bones.

Against disease

A normal admission of drumsticks decreases the opportunity of contracting different sorts of malignant growth. Drumsticks offer security against intestinal malignant growth, skin disease, bosom disease, lung disease and stomach malignancy. The nearness of cancer prevention agents and antioxidantal mixes, for example, phytonutrients, flavanoids and phytochemicals give moringa this mending power. Antioxidantal mixes, for example, quercetin, kaempferol and niaziminin forestall the development of dangerous developments.

For invulnerability

Moringa leaves and blossoms are loaded down with antibacterial properties that wards off disease in the skin and in the throat. They are additionally plentiful in nutrient C which is an incredible enhancer of invulnerability. Moringa lessens the odds of fever, cold and hack.

For the heart

The nutrients and minerals in the drumsticks reinforce the wellbeing of the heart. The rich nourishment filaments in moringa help diminish the degree of awful cholesterol and forestalls against the development of plague in the corridors. It likewise reduces presentation to coronary episodes and heart sicknesses and disarranges, for example, sporadic heartbeat.

Against diabetes

Drumsticks are low on glycemic list and along these lines most appropriate to manage glucose level and keep diabetes under control. It likewise improves the working of the nerve bladder.

Against asthma

Normal admission of drumsticks are likewise acceptable to handle respiratory sicknesses, for example, asthma and irritation of the lungs. The seed-cases are known for their enemy of unfavorably susceptible properties. Aside from forestalling asthma, drumsticks are a great idea to improve breath.

For kidneys

Drumsticks act against the arrangement of stones in kidneys. Moringa juice can counter the destructive impact of certain medications and poisons on kidneys. Drumsticks go about as a bio permeable and evacuates the overwhelming metals and poisons that discover their way to the body.

For the mind

Moringa utilization is useful for the mind. The vegetable forestalls neurological issues. The cell reinforcements in drumsticks can forestall the degeneration of dim issue and diminish the chance of contracting neurological infections, for example, Parkinson's, Alzheimer's and dementia. Progressively finished, the nutrients and minerals found in drumsticks reinforces the neurological framework.

For the blood

Both moringa leaves and seed-units have the ability to cleanse blood. Make a soup or squeeze of moringa and they could decrease your agonies and different skin issues.

For the joints

Drumsticks have mitigating properties that help reduce torment. The seed-units can likewise prepare for gout, stiffness and other provocative illnesses.

For sexual coexistence

The zinc in drumsticks is useful for the sexual coexistence. A few mixes found in moringa can offer comfort from fruitlessness and untimely ejaculation.pregnant ladies Drumsticks can likewise help get rid of the hardships during pregnancy and after labor.

The flexible nourishment

There is a whole other world to drumsticks than the conventional sambar and avial. Drumsticks can likewise be made into a thoran, or matched with jackfruit seeds, or bubbled into a soup. A normal Malayali kitchen has more uses for moringa. Moringa leaves can be blended into the idli or dosa hitter or with the puttu to get the youngsters eat the without making a complain. The leaves will loan flavor and supplements to the normal breakfast things. You can blend them in with chapati batter or cutlets.

At whatever point you get moringa blossoms you can broil them with ground coconut to make an awesome thoran. You will never have enough of it.

Monday, May 14, 2018

Daily aspirin may double skin cancer risk in men: study

Men who take headache medicine day by day may have twofold the danger of melanoma, the most risky kind of skin disease, as per an investigation. Distributed in the Journal of the American Academy of Dermatology, the investigation found that ladies, be that as it may, were not at an expanded danger of melanoma because of anti-inflamatory medicine use.

Given the across the board utilization of headache medicine and the potential clinical effect of the connection to melanoma, patients and human services suppliers should know about the chance of expanded hazard for men," said Beatrice Nardone, an associate teacher at Northwestern University in the US. Nardone recommended expanding tolerant training about sun presentation, abstaining from tanning beds and getting skin checks by a dermatologist, especially for people who are now at high hazard for skin malignant growths.

This doesn't mean men should stop headache medicine treatment to bring down the danger of respiratory failure, she said. The finding is amazing in light of the fact that headache medicine is accounted for to decrease danger of gastric, colon, prostate and bosom disease, Nordone said. One explanation men might be increasingly defenseless could be identified with guys (human and creature species) communicating a lower measure of defensive compounds, similar to superoxide dismutase and catalase, contrasted with females, she said.

'These lower levels of defensive compounds propose that a more elevated level of coming about oxidative cell harm in men may add to the chance of creating melanoma', said Nardone.

Saturday, May 12, 2018

Are babies being introduced to solid food too soon?

Turns out, numerous guardians are spooning up the principal significant pieces of child nourishment to a developing newborn child too early.

The main investigation of a broadly agent gathering of US newborn children detailed that numerous guardians began taking care of their infants nourishments or beverages other than bosom milk or recipe sooner than they should.

Children, who were never breastfed or breastfed for under four months, were well on the way to be acquainted with nourishments too soon.

'Acquainting babies with corresponding nourishments too soon can make them pass up significant supplements that originate from bosom milk and newborn child equation. On the other hand, acquainting them with reciprocal nourishments past the point of no return has been related with micronutrient lacks, hypersensitivities, and more unfortunate eating regimens further down the road,' clarified lead examiner Chloe M Barrera.

Current proposals stipulated that babies ought to be acquainted with corresponding nourishments at around a half year old enough. Breaking down information from the 2009-2014 National Health and Nutrition Examination Survey (NHANES), specialists evaluated the nourishment admission of 1482 youngsters matured six to three years, accumulated during family unit interviews with the kid's intermediary, regularly a parent.

The overview asked how old newborn children were the point at which they were first taken care of something besides bosom milk or equation. This included juice, cow's milk, sugar water, infant nourishment, or whatever else that the baby may have been given, even water.

The discoveries underlined the need to present nourishments at the best possible time to get the most profit by bosom milk or equation.

'Endeavors to help parental figures, families, and medicinal services suppliers might be expected to guarantee that US kids are accomplishing proposals on the planning of nourishment presentation,' said the scientists.

The investigation shows up in the Journal of the Academy of Nutrition and Dietetics.
               

The stronger you are, the healthier your brain is

Turns out, solid quality, estimated by handgrip, means that how sound our cerebrums are.

Utilizing information from the 475,397 members from all around the UK, an examination indicated that by and large, more grounded individuals performed better over each trial of cerebrum working utilized.

Tests included response speed, sensible critical thinking, and various trial of memory.

The examination from the NICM Health Research Institute and Western Sydney University demonstrated the connections were reliably solid in the two individuals matured under 55 and those matured more than 55.

'When considering different factors, for example, age, sexual orientation, bodyweight and training, our examination affirms that individuals who are more grounded improve working minds,' said analyst Joseph Firth.

The investigation additionally indicated that maximal handgrip was unequivocally corresponded with both visual memory and response time in more than one thousand individuals with crazy issue, for example, schizophrenia.

He stated: 'We can see there is an unmistakable association between solid quality and cerebrum wellbeing. However, what we need presently, are more investigations to test on the off chance that we can really make our minds more beneficial by doing things which make our muscles more grounded -, for example, weight preparing."

He included, 'The examination raises the solid chance that weight preparing activities could really improve both the physical and mental working of individuals with these conditions.'

The discoveries are distributed in Schizophrenia Bulletin.

Friday, May 11, 2018

What triggers depression among adults?

Another examination has pinpointed a few qualities that can trigger sadness.

According to the examination led by the University of Edinburgh, about 80 qualities that could be connected to sadness have been found.

The discoveries could help clarify why a few people might be at a higher danger of building up the condition, specialists said.

The examination could likewise assist analysts with creating medications to handle mental sick wellbeing, specialists said.

Gloom influences one of every five individuals in the UK consistently and is the main source of handicap around the world. Life occasions -, for example, injury or stress - can add to its beginning, however it isn't clear why a few people are bound to build up the condition than others.

Researchers broke down information and filtered the hereditary code of 300,000 individuals to recognize regions of DNA that could be connected to wretchedness.

A portion of the pinpointed qualities are known to be engaged with the capacity of neurotransmitters, small connectors that permit synapses to speak with one another through electrical and compound signs.

The researchers at that point affirmed their discoveries by looking at anonymised information held by the individual hereditary qualities and think-tank 23andMe, utilized with the givers' assent.

Educator Andrew McIntosh, who drives the Edinburgh-based research gathering, stated, "Wretchedness is a typical and regularly extreme condition that influences a huge number of individuals around the world. These new discoveries assist us with bettering comprehend the reasons for sorrow and show how the UK Biobank study and enormous information examine has helped advance emotional well-being research."

'We trust that the UK's developing wellbeing information investigate limit will assist us with making significant advances in our comprehension of despondency in coming years', proceeded with McIntosh.

David Howard, the lead creator of the investigation, stated, "This examination distinguishes qualities that possibly increment our danger of gloom, adding to the proof that it is mostly a hereditary issue. The discoveries additionally give new insights to the reasons for wretchedness and we trust it will limit the quest for treatments that could help individuals living with the condition."

Do at-risk adolescents show depressive symptoms on social media?

In danger teenagers are more averse to display burdensome side effects via web-based networking media as they age, finds an investigation.

The exploration proposes that youths with an analysis of discouragement may feel less criticized depicting discouraged state of mind via web-based networking media than recently theorized.

Online networking use can give significant data on the psychological wellness of youths, including their own depictions of their encounters. The motivation behind this examination was to break down the examples of web based life posting portraying burdensome indications among an in danger associate of youths at double cross focuses.

The examination estimated Facebook posts by members at double cross periods, marked Time 1 as youths and Time 2 as youthful grown-ups. Content examination applied the Diagnoses and Statistical Manual (DSM) criteria for sadness to distinguish showed wretchedness indications on Facebook.

The investigation found that the normal number of references to misery among displayers was 9.30 at Time 1 and 4.94 at Time 2, indicating a sensational abatement in posts among teenagers and youthful grown-ups.

'Considering contrasts between posts in Time 1 and Time 2, it is recommended that as teenagers create, the probability to communicate burdensome manifestations is brought down,' said Dr. Kathleen Miller, one of the creators of the examination.
'This might be identified with the advancement of the prefrontal cortex which assumes a job in hindering hasty choices.'

Instances of posts referencing despondency included "Fundamentally at the purpose of surrendering" and "Feeling the most exceedingly terrible at the present time, simply needing to cry." The normal number of references to suicide or self-hurt was .34 at Time 1 and .08 at Time 2.

The examination was introduced during the Pediatric Academic Societies (PAS) 2018 Meeting in Toronto.

Wednesday, May 9, 2018

Nails tell a lot about your health...

Nails and hairs are made of the delicate cells of the skin. Despite the fact that produced using delicate cells, nails are acceptable markers of one's wellbeing and prosperity. For example, on the off chance that one is harrowed by an infection unbeknown to the individual, the primary sign of the shrouded issue gets thought about the nails. In the event that that is the situation, all the nails get influenced soon. The body elements because of infirmity can be ideal and effectively observed on one's finger nails.

A darker tinge at the nail base alongside a whitish shade at the tip of the fingers shows kidney-related infections.

The white half-moon seen at the base of the nails is called lunula. In the event that you notice two lines running corresponding to the lunula with the typical nail shading going through it, it could mean an underneath ordinary pace of egg whites in the blood.

At the point when the finger or toe nail takes on a brilliant white shading with a dull band at the base of the nails, it is commonly a sign of liver infection, particularly cirrhosis.

In numerous occasions, long, dark colored opposite lines become noticeable on nails. This could be the consequence of a response to specific meds like Minocycline, Zidovudine or Phenytoin just as because of the breaking down of pituitary, adrenal and thyroid organs. Lack in Vitamin B 12 also could bring about such an example.

Such glandular failing could achieve changes not exclusively to nails yet in addition to the skin. Just in uncommon cases would this be able to change be a sign of melanoma, a kind of disease. On the off chance that that is the situation, these lines become dark colored and turn noticeable out of nowhere in the old. On the off chance that such signs become noticeable very soon, a careful expert clinical registration is suggested.

Clubbing is another nail abnormality. This distortion of the finger or toe nails shows cardio-vascular sicknesses. Those experiencing liver, kidney and stomach illnesses likewise will in general have clubbed nails.

Nail clubbing or advanced clubbing happens when the nail beds become excessively delicate and the nails structure a more keen edge with the fingernail skin, which is the dead skin at the base of a fingernail or toenail. In such a case, the base of the finger or toe frequently swell.

Single blood test may detect eight types of cancer: study

Researchers have built up a solitary blood test that can help in the early finding of eight regular malignant growth types and recognize the area of the sickness.

The test, called CancerSEEK, is a one of a kind noninvasive, multianalyte test that at the same time assesses levels of eight malignant growth proteins and the nearness of disease quality transformations from circling DNA in the blood.

The test is planned for screening for eight normal malignant growth types that represent more than 60 percent of disease passings in the US, scientists said.

Five of the malignancies secured by the test as of now have no screening test.

'The utilization of a mix of chosen biomarkers for early identification can possibly change the manner in which we screen for malignant growth, and it depends on a similar basis for utilizing mixes of medications to treat tumors,' said Nickolas Papadopoulos, educator of oncology and pathology at Johns Hopkins University in the US.

As indicated by the examination distributed in the diary Science, CancerSEEK is noninvasive and can, on a fundamental level, be managed by essential consideration suppliers at the hour of other routine blood work.

Sleeping for longer may lead to healthier diet: study

Spending an additional hour in bed every night may help decrease the admission of sugary nourishments and lead to a more beneficial eating regimen, as indicated by an examination. Rest is a modifiable hazard factor for different conditions including corpulence and cardio-metabolic sickness, analysts said. The investigation, distributed in the American Journal of Clinical Nutrition, took a gander at the effect of expanding rest hours on supplement consumption.

The specialists from King's College London in the UK found that broadening rest designs brought about a 10-gram decrease in revealed admission of free sugars contrasted with standard levels. They likewise saw patterns for diminished admission of all out starches detailed by the rest expansion gathering.

'The way that stretching out rest prompted a decrease in admission of free sugars recommends that a straightforward change in way of life may truly help individuals to devour more advantageous weight control plans,' said Wendy Hall from King's College London.

The 21 members assigned to the rest expansion bunch attempted a 45-minute rest conference which meant to expand their time in bed by up to 1.5 hours of the night. A further 21 benchmark group members got no mediation in their rest designs. Every member in the rest expansion bunch got a rundown with at least four proper rest cleanliness practices that were customized to their way of life, (for example, keeping away from caffeine before sleep time, setting up a loosening up routine and not hitting the hay excessively full or ravenous) and a prescribed sleep time